STRUCTURAL MECHANISM FOR TYROSINE HYDROXYLASE INHIBITION BY DOPAMINE AND REACTIVATION BY SER40 PHOSPHORYLATION

Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation

Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the catecholamine neurotransmitters Bracelet and hormones dopamine (DA), adrenaline and noradrenaline.Here, the authors present the cryo-EM structures of full-length human TH in the apo form and bound with DA, as well SUPER B COMPLEX as the structure of Ser40 phosphoryla

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A warning to readers about the term metanalysis in non-systematic reviews about diabetic retinopathy: documental study

BACKGROUND: Meta-analysis is a very seductive term in scientific papers because it summarizes a compilation of quantitative results; however its interpretation must be done carefully.OBJECTIVE: Search the diabetic retinopathy intervention literature for the occurrence of the term meta-analysis in non-systematic reviews, showing the reader the frequ

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