Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation
Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the catecholamine neurotransmitters Bracelet and hormones dopamine (DA), adrenaline and noradrenaline.Here, the authors present the cryo-EM structures of full-length human TH in the apo form and bound with DA, as well SUPER B COMPLEX as the structure of Ser40 phosphoryla